The monograph COENZYME Q10 - in health and diseases is a part of the study material of the subject Mitochondrial Medicine, which is included in the pedagogical process at the Medical Faculty of Comenius University in Bratislava.
Our workplace, Pharmacobiochemical laboratory III. The Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava is one of the founders of Mitochondrial Medicine in Slovakia, one of the founders of the importance of coenzyme Q10 in health and disease, under the leadership of Professor Ján Gvozdják, MD, DSc. and Professor Dr. Anna Gvozdjáková, DSc. The result of long-term international cooperation in the field of development of Mitochondrial Medicine and Coenzyme Q10 are monographs:
1. Recent Advances in Mitochondrial Medicine and Coenzyme Q10, NOVA Science, NY, USA, 2018;
2. Mitochondrial Medicine and Coenzyme Q10, HERBA, s.r.o., Bratislava, 2017;
3. Mitochondrial Medicine, Springer, Netherlands, 2008.
Monograph COENZYME Q10 - in health and diseases provides current knowledge about coenzyme Q10. The individual chapters lead the reader from the discovery of coenzyme Q10 by Professor Frederick Löring Crane to the latest information on the metabolism, functions and significance of coenzyme Q10 for the organism.
The chapters are focused on the history and perspective of coenzyme Q10, its characteristics and diagnostic significance. Coenzyme Q10 plays a key role in mitochondrial diseases, in metabolic non-communicable diseases such as cardiovascular and oncological diseases, diabetes mellitus, respiratory diseases and chronic kidney diseases. Primary coenzyme Q10 deficiency is associated with mutations in CoQ genes, with the development of inherited metabolic diseases. Secondary deficiency of coenzyme Q10 is involved in the origin and development of neurological diseases, neurodegenerative diseases such as Parkinson‘s and Alzheimer‘s disease, statin’s-induced myopathy, infertility, aging. Determination of coenzyme Q10 deficiency in the body and its supplementation contributes to the targeted therapy of various, especially mitochondrial diseases. The last but one chapter offers our hypothesis about the effect of SARS-CoV-2 virus on coenzyme Q10 and mitochondrial bioenergetics due to the current pandemic of COVID-19 viral disease.
The monograph is a study literature for students of medical faculties, for doctors and pharmacists who care about disease prevention and our health.